Important Safety Information

Koves LLC is not a medical practice, pharmacy, or healthcare provider.

Koves operates a technology and administrative platform that facilitates access to independent licensed healthcare providers and, when applicable, independent licensed pharmacies.

Koves does not:

• practice medicine;
• diagnose medical conditions;
• determine whether treatment is clinically appropriate;
• prescribe medications;
• select medication dosages;
• manufacture medications;
• compound medications;
• dispense medications; or
• control the independent professional judgment of licensed healthcare providers.

All medical evaluations, diagnoses, treatment recommendations, prescribing decisions, treatment plans, monitoring, and other clinical services are performed by independent licensed healthcare professionals.

Any prescription is issued only when a licensed healthcare provider determines that treatment is medically appropriate for the individual patient.

Prescription medications require evaluation and approval by an appropriately licensed healthcare provider.

Accessing Koves, completing an intake form, enrolling in a program, submitting payment information, or requesting a medication does not guarantee that a prescription will be issued.

A healthcare provider may determine that:

• you are not eligible for treatment;
• a requested medication is not appropriate;
• a different medication or treatment is more appropriate;
• additional medical information is required;
• laboratory testing is required;
• an in-person evaluation is required;
• your treatment should be modified;
• your treatment should be discontinued; or
• you should seek treatment from another healthcare professional.

Some independent healthcare providers accessible through Koves may prescribe compounded medications when they determine that doing so is clinically appropriate and legally permitted.

Compounded medications do not undergo FDA premarket review.

The U.S. Food and Drug Administration does not review compounded medications before they are marketed to verify their safety, effectiveness, or quality in the same manner as commercially manufactured drug products.

Compounded medications may differ from commercially available products in formulation, concentration, inactive ingredients, packaging, stability, route of administration, or other characteristics.

A compounded medication should not be presumed to be equivalent to a commercially manufactured prescription medication.

The availability of compounded medications may change based on applicable law, regulatory requirements, pharmacy availability, ingredient availability, clinical circumstances, and other factors.

Your healthcare provider can discuss whether a commercially manufactured treatment or compounded medication is appropriate for your individual circumstances.

Medication formulations, concentrations, dosing schedules, and administration instructions may vary between patients and dispensing pharmacies.

Always follow the prescription label, instructions provided by the dispensing pharmacy, and instructions from your licensed healthcare provider.

Do not increase, decrease, discontinue, combine, transfer, or otherwise change your prescribed treatment without first consulting your healthcare provider.

Weight-management medications may have overlapping active ingredients but different labeled indications, dosage forms, strengths, administration instructions, and safety labeling. Do not substitute one branded product or presentation for another unless your licensed healthcare provider and dispensing pharmacy specifically direct you to do so.

Wegovy® Injection (semaglutide)

Wegovy injection is a prescription semaglutide GLP-1 receptor agonist. Wegovy carries a boxed warning regarding the potential risk of thyroid C-cell tumors. Do not use Wegovy if you or a family member has a history of medullary thyroid carcinoma (MTC), if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2), or if you have had a serious hypersensitivity reaction to semaglutide or an ingredient in the product.

Serious risks can include acute pancreatitis, gallbladder disease, hypoglycemia when used with insulin or certain diabetes medicines, acute kidney injury due to dehydration, severe gastrointestinal reactions, serious allergic reactions, diabetic retinopathy complications in some people with type 2 diabetes, increased resting heart rate, and pulmonary aspiration during general anesthesia or deep sedation because semaglutide delays gastric emptying. Wegovy is not recommended in patients with severe gastroparesis. Tell every healthcare professional involved in a planned procedure or surgery that you are taking Wegovy.

Common adverse effects include nausea, diarrhea, vomiting, constipation, abdominal pain, headache, fatigue, indigestion, dizziness, abdominal distension, burping, gas, reflux, and other gastrointestinal symptoms. Weight-loss treatment should generally be stopped when pregnancy is recognized; discuss pregnancy planning with your healthcare provider.

Official resources: FDA Wegovy Prescribing Information · Wegovy Prescribing Information & Medication Guide

Zepbound® KwikPen® (tirzepatide)

Zepbound KwikPen is a single-patient-use multi-dose presentation of tirzepatide. The medication risks are the same core tirzepatide risks described for other Zepbound presentations below. Zepbound carries a boxed warning for risk of thyroid C-cell tumors observed in rats; the human relevance is unknown. Do not use Zepbound if you or a family member has a history of MTC, if you have MEN 2, or if you have had a serious hypersensitivity reaction to tirzepatide or an ingredient in the product.

Never share a Zepbound KwikPen between patients, even if the pen needle is changed. Sharing can create a risk of transmission of blood-borne pathogens. Use a new compatible pen needle for each injection and follow the Instructions for Use supplied with the exact device dispensed to you.

Tirzepatide can cause severe gastrointestinal reactions and is not recommended in people with severe gastroparesis. Other serious risks include pancreatitis, gallbladder disease, dehydration-related kidney injury, hypoglycemia when combined with certain glucose-lowering medicines, serious hypersensitivity reactions, diabetic retinopathy complications in some people with type 2 diabetes, and pulmonary aspiration during anesthesia or deep sedation. Tirzepatide delays gastric emptying and can affect absorption of oral medicines.

Zepbound may reduce the effectiveness of oral hormonal contraceptives after treatment is started and after dose increases. Patients using oral hormonal contraceptives should discuss temporary use of a non-oral method or an additional barrier method with their healthcare provider. Zepbound may cause fetal harm and should be discontinued when pregnancy is recognized.

Official resource: Zepbound U.S. Prescribing Information

Zepbound® Single-Dose Pen (tirzepatide)

The single-dose Zepbound autoinjector contains tirzepatide for one subcutaneous dose. The boxed thyroid tumor warning, contraindications, pregnancy precautions, medication interactions, and serious adverse-reaction profile described above for tirzepatide apply. Do not reuse a single-dose pen and follow the manufacturer Instructions for Use for the exact strength dispensed.

Official resource: Zepbound U.S. Prescribing Information

Zepbound® Vial (tirzepatide)

Zepbound is available in vial presentations. Depending on the product dispensed, a vial may be single-dose or part of a multi-dose presentation. The same core tirzepatide warnings and contraindications described above apply. Vials require careful measurement and administration; use only the syringe, needle, volume, and technique directed by the dispensing pharmacy, Instructions for Use, and your licensed healthcare provider. Never estimate a dose or transfer instructions from a different concentration or presentation.

Official resource: Zepbound U.S. Prescribing Information

Ozempic® (semaglutide)

Ozempic is a prescription semaglutide injection for type 2 diabetes and certain cardiovascular and kidney-risk indications in eligible adults. Ozempic is not the same product or indication as Wegovy. If a licensed healthcare provider prescribes Ozempic, follow the Ozempic label and individualized treatment plan rather than instructions for another semaglutide product.

Ozempic carries a boxed warning regarding thyroid C-cell tumors observed in rodents and is contraindicated in people with a personal or family history of MTC, MEN 2, or a serious hypersensitivity to semaglutide. Serious risks include pancreatitis, diabetic retinopathy complications, hypoglycemia when combined with insulin or certain diabetes medicines, dehydration-related kidney injury, severe gastrointestinal reactions, serious allergic reactions, gallbladder disease, and pulmonary aspiration during anesthesia or deep sedation. Never share an Ozempic pen between patients, even if the needle is changed.

Official resources: Ozempic U.S. Prescribing Information · Ozempic Prescribing Information Page

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Important Safety Information

NAD+ (nicotinamide adenine dinucleotide) may be offered through a compounded prescription formulation when prescribed by an independent licensed healthcare provider.

Compounded NAD+ injection has not undergone FDA premarket review. FDA has not reviewed a compounded NAD+ formulation for safety, effectiveness, or quality before marketing.

Formulation, concentration, inactive ingredients, dosing, and administration instructions may differ depending on the dispensing pharmacy and individual prescription.

Before Using NAD+

Tell your healthcare provider about allergies, kidney or liver disease, chronic or significant medical conditions, pregnancy or breastfeeding, and all prescription medications, supplements, and injectable therapies you use.

Possible Side Effects

Possible reactions may include injection-site pain, redness, swelling or irritation, nausea, lightheadedness, flushing or warmth, headache, and hypersensitivity or allergic reactions.

Important Safety Information

Sermorelin is a synthetic analog of growth hormone-releasing hormone (GHRH) that stimulates the pituitary gland to release growth hormone. If sermorelin is prescribed through a compounded formulation, the compounded medication itself has not undergone FDA premarket review and has not undergone FDA premarket review for safety, effectiveness, or quality.

Before Using Sermorelin

Tell your healthcare provider about your complete medical history, including pituitary or endocrine disorders, diabetes or blood-sugar problems, cancer or a history of malignancy, pregnancy or breastfeeding, allergies, and all medications, supplements, peptides, hormones, and injectable therapies you use.

Warnings and Possible Side Effects

Sermorelin may increase growth hormone activity and insulin-like growth factor 1 (IGF-1). Your healthcare provider may determine that laboratory monitoring is appropriate during treatment.

Possible adverse effects may include injection-site pain, redness, swelling or irritation, flushing, headache, dizziness, nausea, and hypersensitivity or allergic reactions. Changes related to increased growth hormone or IGF-1 activity may also occur.

Seek immediate medical attention for symptoms of a serious allergic reaction, including difficulty breathing, swelling of the face, lips, tongue, or throat, severe rash, fainting, or other severe symptoms.

Important Safety Information

Glutathione is a naturally occurring tripeptide composed of amino acids. Injectable glutathione may be prescribed through a compounded formulation when determined appropriate by an independent licensed healthcare provider.

Compounded glutathione injections have not undergone FDA premarket review. FDA has not approved a compounded glutathione injection for a specific therapeutic indication, dosage, or safety profile.

Before Using Glutathione

Tell your healthcare provider about allergies, asthma or respiratory disorders, liver or kidney disease, G6PD deficiency or other blood disorders, cancer treatment, pregnancy or breastfeeding, and all medications and supplements.

Possible Side Effects

Possible adverse effects may include injection-site pain, redness, swelling or irritation, headache, lightheadedness, flushing, nausea, abdominal discomfort, diarrhea, fatigue, and allergic or hypersensitivity reactions.

Important Safety Information

Glutathione is a naturally occurring tripeptide composed of amino acids. A compounded intranasal glutathione preparation may be prescribed when determined appropriate by an independent licensed healthcare provider.

Compounded glutathione preparations have not undergone FDA premarket review. FDA has not approved a compounded glutathione preparation for a specific therapeutic indication, dosage, or safety profile, and has not reviewed an intranasal formulation for safety, effectiveness, or quality before marketing.

Formulation, concentration, inactive ingredients, dosing, and administration instructions may differ depending on the dispensing pharmacy and individual prescription.

Before Using Glutathione Nasal Spray

Tell your healthcare provider about allergies, asthma or other respiratory disorders, nasal or sinus conditions including recent nasal surgery or injury, liver or kidney disease, G6PD deficiency or other blood disorders, cancer treatment, pregnancy or breastfeeding, and all medications and supplements.

Possible Side Effects

Possible adverse effects may include nasal irritation, burning or stinging, sneezing, runny or blocked nose, nosebleed, altered sense of smell or taste, throat irritation, headache, lightheadedness, nausea, and allergic or hypersensitivity reactions.

Do not share a nasal applicator with anyone else. Seek immediate medical attention for symptoms of a serious allergic reaction, including difficulty breathing, swelling of the face, lips, tongue, or throat, severe rash, fainting, or other severe symptoms.

Important Safety Information

"Lipo-C" refers to a compounded injectable preparation that may be prescribed when determined appropriate by an independent licensed healthcare provider. There is no single standard formulation.

Compounded preparations have not undergone FDA premarket review. FDA has not reviewed a compounded lipo-C preparation for safety, effectiveness, or quality before marketing, and has not approved it for any specific therapeutic indication, dosage, or safety profile.

Components, concentration, inactive ingredients, dosing, and administration instructions may differ depending on the dispensing pharmacy and individual prescription. Your prescription and the dispensing pharmacy's instructions are the authoritative description of what you have been prescribed.

Before Using Lipo-C

Tell your healthcare provider about allergies, kidney or liver disease, chronic or significant medical conditions, any vitamin or nutrient deficiency you have been told about, pregnancy or breastfeeding, and all prescription medications, supplements, and injectable therapies you use.

Possible Side Effects

Possible adverse effects may include injection-site pain, redness, swelling or irritation, flushing or warmth, headache, lightheadedness, nausea, and hypersensitivity or allergic reactions.

Seek immediate medical attention for symptoms of a serious allergic reaction, including difficulty breathing, swelling of the face, lips, tongue, or throat, severe rash, fainting, or other severe symptoms.

Sexual-health medications can have clinically important cardiovascular, neurologic, psychiatric, and drug-interaction risks. Tell your provider about heart disease, blood-pressure problems, recent heart attack or stroke, vision or hearing disorders, bleeding disorders, penile anatomical conditions, kidney or liver disease, and every prescription, over-the-counter, recreational, and supplement product you use.

Sildenafil

Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor used for erectile dysfunction in appropriately selected patients. Do not use sildenafil with nitrates such as nitroglycerin or isosorbide because the combination can cause a dangerous drop in blood pressure. Sildenafil is also contraindicated with guanylate-cyclase stimulators such as riociguat.

Use caution with alpha-blockers, antihypertensives, substantial alcohol intake, and medicines that strongly affect CYP3A4. Serious adverse effects can include symptomatic hypotension, an erection lasting more than 4 hours (priapism), sudden vision loss associated with non-arteritic anterior ischemic optic neuropathy (NAION), and sudden decrease or loss of hearing. Common effects include headache, flushing, indigestion, nasal congestion, visual changes, dizziness, and back or muscle pain. Seek emergency care for an erection lasting more than 4 hours.

Official resource: DailyMed sildenafil Label

Tadalafil

Tadalafil is a phosphodiesterase type 5 (PDE5) inhibitor used for erectile dysfunction in appropriately selected patients. Do not use tadalafil with nitrates, and do not use it with guanylate-cyclase stimulators such as riociguat. The same major PDE5-inhibitor warnings regarding hypotension, priapism, sudden vision loss, and sudden hearing loss apply.

Because tadalafil has a longer duration of action than some other PDE5 inhibitors, clinically important interactions may persist after a dose. Tell emergency and other healthcare professionals when tadalafil was last taken, especially if nitrate treatment might otherwise be considered. Use caution with alpha-blockers, antihypertensives, strong CYP3A4 inhibitors, kidney or liver impairment, and substantial alcohol use.

Official resource: DailyMed tadalafil Label

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Anti-aging treatments offered through the platform are compounded medications. Compounded medications do not undergo FDA premarket review for safety, effectiveness, or quality. A licensed provider decides whether any of them is appropriate for you.

Compounded NAD+

Possible reactions may include injection-site pain, redness, swelling or irritation, nausea, lightheadedness, flushing or warmth, headache, and hypersensitivity or allergic reactions. Seek immediate medical attention for symptoms of a serious allergic reaction. Tell your provider about any side effect you experience.

Tell your provider first: Allergies, kidney or liver disease, chronic or significant medical conditions, pregnancy or breastfeeding, and every prescription medication, supplement and injectable therapy you use. Injectables interact with more than people expect, and the visit is where that gets caught.

Compounded Sermorelin

Possible adverse effects may include injection-site pain, redness, swelling or irritation, flushing, headache, dizziness, nausea, and hypersensitivity or allergic reactions. Seek immediate medical attention for symptoms of a serious allergic reaction, including difficulty breathing, swelling of the face, lips, tongue or throat, severe rash or fainting.

Tell your provider first: Your complete medical history, and specifically pituitary or endocrine disorders, diabetes or blood-sugar problems, cancer or a history of malignancy, pregnancy or breastfeeding, allergies, and all medications, supplements, peptides, hormones and injectable therapies you use. Your provider may decide laboratory monitoring is appropriate during treatment.

Compounded Glutathione (injection)

Possible adverse effects may include injection-site pain, redness, swelling or irritation, headache, lightheadedness, flushing, nausea, abdominal discomfort, diarrhea, fatigue, and allergic or hypersensitivity reactions. Seek immediate medical attention for symptoms of a serious allergic reaction. Tell your provider about any side effect you experience.

Tell your provider first: Allergies, asthma or respiratory disorders, liver or kidney disease, G6PD deficiency or other blood disorders, cancer treatment, pregnancy or breastfeeding, and all medications and supplements. G6PD deficiency in particular is the kind of thing people do not know they have and the visit is where it gets asked about.

Compounded Glutathione Nasal Spray

Possible adverse effects may include nasal irritation, burning or stinging, sneezing, runny or blocked nose, nosebleed, altered sense of smell or taste, throat irritation, headache, lightheadedness, nausea, and allergic or hypersensitivity reactions. Do not share a nasal applicator with anyone else. Seek immediate medical attention for symptoms of a serious allergic reaction.

Tell your provider first: Allergies, asthma or other respiratory disorders, nasal or sinus conditions including recent nasal surgery or injury, liver or kidney disease, G6PD deficiency or other blood disorders, cancer treatment, pregnancy or breastfeeding, and all medications and supplements. Anything about your nose matters here in a way it would not for an injection.

Compounded Lipo-C

Possible adverse effects may include injection-site pain, redness, swelling or irritation, flushing or warmth, headache, lightheadedness, nausea, and hypersensitivity or allergic reactions. Seek immediate medical attention for symptoms of a serious allergic reaction. Tell your provider about any side effect you experience.

Tell your provider first: Allergies, kidney or liver disease, chronic or significant medical conditions, any vitamin or nutrient deficiency you have been told about, pregnancy or breastfeeding, and every prescription medication, supplement and injectable therapy you use.

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Contact your licensed healthcare provider regarding side effects, worsening symptoms, unexpected reactions, concerns regarding treatment, or questions about whether you should continue treatment.

You may also contact the pharmacy that dispensed your prescription regarding medication quality, labeling, storage, ingredients, formulation, or dispensing concerns.

Patients and healthcare professionals may voluntarily report suspected adverse events and product-quality problems to the FDA MedWatch program.

FDA MedWatch: 1-800-FDA-1088

KOVES IS NOT AN EMERGENCY MEDICAL SERVICE. DO NOT USE KOVES CUSTOMER SUPPORT, EMAIL, TEXT MESSAGING, WEBSITE FORMS, OR ROUTINE PROVIDER MESSAGING FOR AN EMERGENCY.

Seek emergency medical care immediately if you believe you are experiencing a serious or life-threatening reaction.

Examples may include:

• difficulty breathing;
• swelling of the face, lips, tongue, or throat;
• loss of consciousness;
• severe chest pain;
• severe or persistent abdominal pain;
• severe dehydration;
• signs of anaphylaxis;
• severe confusion;
• seizure;
• other severe or rapidly worsening symptoms; or
• any condition you reasonably believe requires immediate medical attention.

Call 911 or seek care at the nearest emergency department.

Advertising, treatment descriptions, product pages, photographs, testimonials, illustrations, before-and-after examples, customer experiences, or other promotional materials appearing on or relating to Koves are intended to provide general information regarding Koves services.

Advertising does not constitute a representation that a particular medication or treatment is medically appropriate for you.

Some promotional materials may include actors, models, illustrative scenarios, customer experiences, or paid endorsements. Where disclosure is required, Koves will identify sponsored or compensated endorsements as applicable.

Individual results vary. No specific medical, cosmetic, wellness, weight-loss, performance, longevity, or other outcome is guaranteed.

The medication summaries above are intentionally concise and do not replace the current prescribing information, Medication Guide, Instructions for Use, pharmacy labeling, or individualized medical advice. Product labeling can change. When there is any difference between this page and the current label for the exact medication dispensed, the current official label and your licensed healthcare provider's instructions control.

• DailyMed — current FDA-submitted drug labeling
• FDA Drugs@FDA — approvals, labels, and regulatory history
• FDA MedWatch — safety information and adverse-event reporting
• FDA Compounding Risk Alerts
• FDA Drug Safety Communications

Third-party medication names, brand names, logos, trademarks, and service marks referenced by Koves remain the property of their respective owners.

Reference to a third-party medication or manufacturer does not imply affiliation, sponsorship, or endorsement unless expressly stated.

This safety information is not comprehensive and does not contain all possible uses, contraindications, warnings, precautions, drug interactions, adverse reactions, or other information concerning the medications discussed.

Medication labeling and safety information may change as additional information becomes available.

Always review information supplied with your prescription and consult your licensed healthcare provider and dispensing pharmacy regarding your individual treatment.

Questions concerning Koves services, billing, account access, or website information may be directed to:

Koves LLC
Email: hello@koves.co
Website: Koves.co

Medical questions concerning your diagnosis, medication, prescription, dosage, treatment plan, symptoms, side effects, or clinical care should be directed to your licensed healthcare provider using the applicable clinical communication channel.

IF YOU ARE EXPERIENCING A MEDICAL EMERGENCY, CALL 911 OR SEEK IMMEDIATE EMERGENCY MEDICAL ATTENTION.